The Orbitrap IQ-X Tribrid Mass Spectrometer coupled with Vanquish Flex Duo with Dual UPLC for metabolomics applications.
Applications
- Metabolite Annotation: Separation of metabolites with MS/MS and MSn analysis using CID and HCD fragmentation for improved characterization
- Sensitive Detection: AcquireX, using repeat injections, improves detection of low abundance metabolites by increased fragmentation spectra and confidence in spectral matches
- Separation Flexibility: Vanquish Duo with Dual. UPLC with split sampler accommodates up to 3 columns for separation of multiple classes of metabolites or for column switching
- Column options: Reverse Phase C18 and HILIC for nonpolar and polar metabolomic UPLC separation and CSH C18 column for lipidomic separation
Features
Thermo Orbitrap IQ-X Tribrid Mass Spectrometer
- Mass Analyzers: Quadrupole, Linear Ion Trap and Orbitrap Mass Analyzers
- Fragmentation/Activation: CID and HCD
Vanquish Flex UPLC Duo with Dual
- UPLC flow up to 1 ml/min
- Autosampler loading from vials or well plates of 0.01 to 25 ul injections
- Dual Split sampler to inject onto columns with different solvent systems
- Duo 2 column compartment for alternating sample and wash runs
Metabolomics Software
- Compound Discoverer: Database search algorithms for compound annotation and quantitation of multiple samples
- LipidSearch: Lipid molecule search and annotation for untargeted lipid identification
- TraceFinder: Optimize for targeted screening and routine quantitation
- Mass Frontier: Using fragmentation for structural characterization and confident metabolite identification
Is Ongoing
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