Research Core Facility Directory

The Advanced Protein Therapeutics (APT) Core at UT Austin supports the development of therapeutic proteins through a suite of cutting-edge services. Specializing in protein engineering, production, and biophysical characterization, the APT provides researchers with access to high-throughput phage, bacteria, yeast, and mammalian library platforms and state-of-the-art analytical tools. Core services include custom protein expression, discovery, engineering, purification, and characterization of next generation antibodies and enzymes. APT staff work closely with investigators, offering technical expertise and collaborative support to advance therapeutic innovations.

Services Offered

• Strategic protein library design & screening
• Custom protein expression & purification
• Biophysical & mechanistic characterization
• Collaboration on therapeutics development
• Training on protein engineering techniques

The Biological Mass Spectrometry Facility is the primary unit providing advanced mass spectrometry services for proteomics and protein modification analyses and protein molecular weight determination at the University. Equipped with state-of-the-art Thermo Orbitrap Ascend and Fusion mass spectrometers, the facility supports both quantitative and qualitative studies. In addition, a Bruker Autoflex self-service instrument is available for researchers to use MALDI-TOF/TOF mass spectrometry, and untargeted metabolomics experiments are conducted on a Thermo QExactive mass spectrometer. The facility staff offer expertise and guidance, ensuring researchers have access to the tools and support needed for cutting-edge biological research.

Services Offered

• Proteomics and protein modification analysis
• Protein molecular weight determination
• Quantitative and qualitative mass spectrometry
• Access to Thermo Orbitrap Ascent and Fusion instruments
• Self-service biomolecule mass spectrometry using MALDI-TOF
• Untargeted metabolomics with high resolution QExactive
• Consultation and collaboration on experimental design and data analysis for mass spectrometry projects

The Biomedical Imaging Center (BIC) is an interdisciplinary, multimodal imaging facility that supports human and preclinical imaging research at the University of Texas and the wider community. The BIC spans 3 locations in the Norman Hackerman (NHB) and the Health Discovery (HDB) Buildings on the UT campus and hosts a range of systems for MRI, PET, CT and optical imaging. The Center accommodates both independent and assisted use (for human MRI and PET/CT) is on its instruments and provides in-house training in scanner safety and operation for independent users. The facility also supports a range of task / response paradigms for functional MRI (fMRI) studies and provides back-end support for data archiving, management and common analyses.

Services Offered

• Basic, translational and clinical-research involving human or preclinical imaging
• Initial consultation on establishing an imaging research project or program at BIC
• Development / implementation of MRI / fMRI protocols on our 3T and 7T systems
• Ongoing project advice and technical support for the imaging systems and ancillary equipment
• Educational courses on imaging physics and technology
• Training in scanner safety including MRI Level 1 certification
• Training in scanner-operation for our systems including MRI Level 2 certification
• Assisted scanning on the Siemens Prisma, Siemens Vida and GE Discovery systems
• Post-study support for data archiving, management and common analyses

The Bureau of Economic Geology (BEG) at UT Austin is a leading research institute dedicated to advancing the understanding of energy resources, environmental systems, and geological processes. As the oldest research unit at UT, BEG integrates cutting-edge science with practical applications, supporting industry, government, and public interest in areas such as energy exploration, carbon storage, water resource management, and environmental sustainability. BEG's multidisciplinary teams conduct innovative research and provide expertise, facilities, and data resources that drive scientific discovery and inform policy. The Bureau’s collaborative environment enables impactful research with global reach and real-world applications.

Services Offered

• Energy and environmental research
• Geological sample and data resources
• Industry and government partnerships
• Policy research on sustainability
• Training for geoscience professionals

The Center for Biomedical Research Support (CBRS) is the administrative unit dedicated to advancing biomedical research by providing cutting-edge technologies and expert guidance tailored to the diverse needs of researchers. The center offers high-resolution light and electron microscopy, precise cell-sorting techniques, complex sequencing projects, mass spectrometry analyses, and customized transgenic mouse models. CBRS staff deliver personalized training and support to ensure research success. Additionally, the STEM Stockroom and freezer supply core provide a wide range of laboratory supplies, while our computing infrastructure and bioinformatics consultants assist in extracting insights from data. CBRS serves as a vital resource for researchers seeking to drive progress in biomedical science.

Services Offered

• High-resolution light and electron microscopy
• Advanced cell sorting and flow cytometry
• Mass spectrometry and proteomics
• Genomic and bioinformatics support
• Training and consultation for lab techniques

The Bard Center for Electrochemistry maintains a unique user electrochemical research instrumentation facility, allowing researchers from the University of Texas and visitors access to instrumentation and expert help in electrochemical studies. In a single location, the facility makes available electrochemical instruments such as potentiostats, scanning electrochemical microscopes, impedance analyzers, optical profilers, etc., for studying intermediates on electrode surfaces and device test equipment

Services Offered

• Electrochemical analysis and testing
• Custom Electrochemical cell design
• Electrochemical data interpretation
• Training in Electrochemical techniques
• Advanced instrumentation for redox and reaction studies
• Access to high-precision Electrochemical measurement systems

The Electron Paramagnetic Resonance Spectroscopy (EPR) Facility at UT Austin's Department of Chemistry features a Bruker EMX Plus spectrometer equipped for X-band and Q-band EPR, as well as ENDOR and variable temperature studies. This facility supports a wide range of research applications by providing researchers access to sophisticated EPR instrumentation and expertise. The facility is committed to facilitating advanced investigations into paramagnetic species, enhancing the understanding of materials at the molecular level.

Services Offered

• EPR spectroscopy for paramagnetic sample analysis
• Custom EPR experimental design
• Sample preparation and support for paramagnetic studies
• Training in EPR data collection and interpretation
• High-resolution spectrometers for a range of biological and material applications

The Genomic Sequencing and Analysis Facility (GSAF) offers next generation sequencing (NGS) services focusing on short read sequencing platform ranging from whole genome sequencing to single cell application. The facility provides the community with technical expertise and experience to support ongoing research projects.

Services Offered

• High-throughput DNA and RNA sequencing
• Sanger sequencing for longer DNA reads
• Quality control and data validation
• Bioinformatics support for data analysis
• Consultation on experimental design for genomics research
• Access to sequencing instrumentation and software

The i4Health Center at UT Austin focuses on transforming healthcare through innovative research and education in informatics, analytics, and technology. The center promotes interdisciplinary collaboration among faculty, students, and industry partners to develop solutions for improving health outcomes. i4Health engages in various initiatives, including data-driven research, educational programs, and outreach activities, aiming to enhance healthcare delivery and patient engagement.

Services Offered

• Research and development for healthcare solutions
• Health informatics and data analytics
• Clinical trials and translational research support
• Partnerships with healthcare providers and industry
• Training in health-focused innovation and technology

Isotope Ratio Mass Spectrometry EA-ISOLINK – Delta V IRMS

Carbon and nitrogen isotopic composition of solid samples (sediment, soil, nutrient filters, tissues)

GASBENCH – Delta V IRMS

• Carbon and oxygen isotopic composition of carbonates
• Oxygen and hydrogen isotopic composition of water
• Carbon isotopic composition of dissolved inorganic carbon. GC-ISOLINK – Delta V IRMS
• Compound specific carbon, nitrogen and hydrogen isotopic compositions of fatty acids, alkanes, alcohols, amino acids

LC-ISOLINK – Delta Q IRMS

Carbon isotope composition of liquid phased compounds

Mass Spectrometry LC-Ion-Mobility-Quadrupole-Time-of-Flight-Mass-Spectrometry

Provide accurate mass detection, molecular discovery, and quantification of analytes, including but not limited to, proteins, metabolites, lipids and carbohydrates. Agilent 6560 LC/MS IM-QTOF.

Elemental and Nutrient Analysis LACHAT QUIKCHEM

Quantify nutrients (ammonium, nitrate, silicate, phosphate) in aqueous samples (seawater, river water, groundwater)

TOC/TDN

Total organic carbon and total dissolved nitrogen abundance measurements in aqueous samples (seawater, river water, groundwater)

Services Offered

• Analytical services for marine and environmental samples
• Coastal and marine ecosystem monitoring
• Sample analysis for chemical and biological parameters
• Collaborative research in marine science and oceanography

The Mass Spectrometry Imaging Facility at UT Austin enables high-resolution molecular imaging for biomedical research, using Matrix Assisted Laser Desorption/Ionization (MALDI) techniques to map biomolecules in tissues. With capabilities in Histology-Guided Mass Spectrometry (HGMS) and biofluid profiling, the facility supports research in cancer, neurodegenerative diseases, and more. Staff provide specialized imaging, data analysis, and training, advancing insights in cellular and molecular pathology.

Services Offered

• High-resolution mass spectrometry for chemical and biological samples
• Quantitative and qualitative analysis
• Proteomics and metabolomics studies
• Method development for custom mass spectrometry applications
• Data interpretation and consultation

The Mass Spectrometry Imaging Facility at UT Austin provides cutting-edge tools for spatially resolved chemical analysis of biological and material samples. Using advanced mass spectrometry techniques, the facility enables high-resolution molecular imaging for applications in biomolecular research, pharmaceuticals, and materials science. Services include sample preparation, data acquisition, and interpretation of spatial distributions of biomolecules, metabolites, and other compounds. The facility offers expert guidance and collaboration opportunities to support researchers in gaining detailed chemical insights at the microscale.

Services Offered

• Imaging mass spectrometry for spatial analysis of samples
• Chemical mapping of biological and material specimens
• High-resolution molecular imaging
• Support for research in biomolecular and tissue analysis
• Data analysis and visualization services

The Microscopy and Imaging Facility provides extensive microscopy equipment and services for ultra-structural analysis of a variety of sample types. The facility offers assisted use and training on its instrumentation and consultations on microscopy- and spectroscopy-related research.

Services Offered

• Nanofabrication and microfabrication facilities
• Semiconductor device prototyping
• Cleanroom access and support
• Training in photolithography, etching, and thin-film deposition
• Collaborative research in electronics and materials science

The Microscopy & Flow Cytometry Facility is the unit responsible for providing access to advanced light microscopes, flow cytometers, and cell sorters for research and teaching at the University. The facility supports users from all disciplines, offering both standard and high-end instrumentation. In addition to assisted use, the facility provides training on equipment and consultations to help researchers optimize their use of the available tools. Staff scientists work closely with investigators, ensuring access to the expertise and resources needed for cutting-edge imaging research.

Services Offered

• Light microscopy
• Confocal and fluorescence microscopy
• Flow cytometry
• Cell sorting
• Analysis workstations
• Training in microscopy and flow cytometry techniques
• Consultation on experimental design for microscopy and flow cytometry studies

The Mouse Genetic Engineering Facility (MGEF) provides expert advice and custom services to generate, cryopreserve, and rederive genetically engineered mice for understanding mammalian gene function and human disease. The MGEF serves as a central hub for mouse genetics at UT by providing precision mouse models and transgenic services, engaging in teaching, training, and collaborative projects, and undertaking research that supports the core’s mission. The facility is a key resource for researchers across various disciplines, including those studying alcohol addiction, neurodegeneration, immunology, cancer, and developmental disorders.

Services Offered

• Design and generation of precision mouse models
• Cryopreservation of mouse lines
• Cryorecovery of mouse models from repositories
• Embryo manipulation for -omic studies

The Nuclear Magnetic Resonance (NMR) Facility at UT Austin provides researchers with high-resolution spectroscopic capabilities for structural analysis of organic, inorganic, and biomolecular compounds. Equipped with a range of state-of-the-art NMR spectrometers, the facility supports applications in chemistry, materials science, and pharmaceutical research. Services include routine and advanced NMR experiments, data interpretation, and user training. The facility also offers expert consultation for customized experimental setups, ensuring researchers have the tools and expertise needed for detailed molecular characterization.

Services Offered

• High-resolution NMR spectroscopy
• Analysis of molecular structure and dynamics
• Customizable NMR experimental setups
• Training in NMR data interpretation and experimental design

The Multiphoton/Confocal Microscope is a state-of-the-art, high-resolution imaging system designed for multi-platform applications. This advanced microscope is particularly well-suited for the bioscience and biomedical engineering fields, enabling high-speed, high-resolution image capture in various modes without disturbing the sample. Its versatility and precision make it an invaluable tool for researchers conducting detailed studies in dynamic biological environments.

Services Offered

• High-resolution 2-photon and confocal microscopy
• Imaging of live cells and tissues
• Multi-modal fluorescence capabilities
• Support for biomedical and life sciences research

The Sauer Structural Biology Laboratory is a state-of-the-art cryo-EM facility that houses a TFS Titan Krios and a TFS Glacios. The Krios is equipped with a Gatan BioContinuum imaging filter and K3 direct electron detector, enabling its use for high-resolution single-particle and tomographic imaging of macromolecular machines. The TFS Glacios is equipped with a TFS Falcon IV direct electron detector for high-resolution single-particle imaging and a TFS CETA-D camera for high-resolution micro -ED data. The facility also houses the equipment required for high-resolution structure determination of thin vitrified samples.

Services Offered

• Cryo-electron microscopy for macromolecular imaging
• High-resolution structure determination
• Sample preparation for cryo-EM
• Data analysis and visualization for structural biology research

The Targeted Therapeutic Drug Discovery & Development Program (TTP) is the administrative unit responsible for providing access to advanced technologies and expertise that facilitate the translation of research into new cancer treatments. The program focuses on supporting cancer scientists and clinicians through an integrated approach to targeted molecular drug discovery, bringing together key disciplines to achieve their research goals within a unified platform. TTP staff collaborate closely with investigators, ensuring they have the resources and guidance needed for successful therapeutic development

Services Offered

• Drug discovery and development support for cancer therapies
• Screening and validation of therapeutic targets
• Collaboration with cancer researchers and clinicians
• Translational research to bring therapies to clinical trials

Progression through the drug development process ranges from characterization of the lead compound to in vivo efficacy studies. At TherapeUTex, our goal is to aid and guide the development of drug products and technologies through this development process by providing services including drug formulation and delivery, in vitro and in vivo preclinical and proof-of-concept studies, lab-scale formulation, stability studies, and production. State-of-the-art analytical technologies and facilities at TherapeUTex provide the necessary tools to deliver the trustworthy results our customers expect. Our scientists, together with collaborating scientists from academia and industry, provide broad expertise in the pharmaceutical and biotech fields, with the flexibility to customize projects tailored to our clients’ needs.

Services Offered

• Drug Formulation and Delivery
• Preclinical and Proof-of-Concept Studies
• Lab-Scale Formulation and Stability Testing
• Analytical Services
• In Vivo Modeling