Creating Zonally Organized Articular Cartilage from Marrow Stromal Cells: A Biomaterials Approach

Life Sciences : Therapeutics

Available for licensing

Inventors

  • Krishnendu Roy, Ph.D. , Biomedical Engineering
  • Lonnissa Nguyen , Biomedical Engineering

Background/unmet need

Biomaterials hold great promise for medicine and research; however, current cartilage tissue engineering methods lack the capability to stimulate the formation of functional and structurally relevant cartilage tissue. The previous approaches produced a homogeneous tissue type by encapsulating chondrogenic cells uniformly within a polymer matrix to mimic the overall properties of articular cartilage. These fabrication methods for cartilage tissue regeneration often yield a bulk tissue with bulk properties that do not necessarily mimic the properties of native articular cartilage.

Invention Description

Researchers at The University of Texas at Austin have developed an innovative strategy for regenerating structurally organized cartilage tissue which has the capability of mimicking the zonal characteristics of natural articular cartilage. This technology offers the advantage of regenerating cartilage tissue that more closely matches native articular cartilage in structure and function. This technology uses novel bio-material compositions used to fabricate a three-dimensional multi-layered hydrogel scaffold capable of inducing stem cell differentiation into zone-specific chrondrocytes.

Benefits/Advantages

  • The use of stem cells eliminates the need for donor tissue
  • Produces mechanically-relevant tissue

Features

  • Fabricate biocompatible 3-D multilayer hydrogel structures
  • Simultaneously differentiate a single stem cell population into zone-specific chondrocytes

Market potential/applications

 Cartilage engineering and tissue regeneration

IP Status