Novel Polymers and Methods for Economical Drug Loading and Controlled Release

Life Sciences : Drug Delivery

Available for licensing

Inventors

  • Nicholas Peppas, Sc.D. , Biomedical Engineering
  • Mark Byrne, Ph.D. , Chemical Engineering
  • James Hilt, Ph.D. , Chemical and Materials Engineering

Background/unmet need

Polymer drug delivery carriers are an essential component of current strategies for the delivery of many pharmaceuticals. However, these polymer carriers often need to be tailored individually for different drugs. Also, many of these polymers exhibit poor loading efficiencies due to the delicate interplay between drug solubility (Classes I, II, III and IV in the BCS classification system of the FDA) and polymer characteristics. This requires an increased amount of polymer carrier that could in turn be delivered along with the drug.

Although these polymers are believed to be safe, long-term use of drugs delivered with these polymers could lead to their accumulation with adverse affects. Polymer drug delivery systems with improved loading capacity could prevent or slow down the unfavorable accumulation of residual drug carriers in the body.

Invention Description

A new method for the development of drug delivery carriers has been developed. A novel and flexible polymer synthesis technique allows for the creation of high-loading-capacity controlled-release devices. This technique produces drug delivery carriers that are molecularly tailored to a desired drug molecule and releases with desirable profiles using biocompatible polymer materials. This method may be applied to both biodegradable and non-biodegradable carriers.

Benefits/Advantages

  • Control over the loading and release of a given drug molecule
  • Capable of tailoring to a specific drug molecule
  • High drug-loading efficiency
  • Flexibility of the synthesis technique

Features

  • Biocompatible polymer materials
  • Technique is applicable to a wide variety of drug molecules

Market potential/applications

According to Fuji-Keizai U.S.A., a leading market research firm, the U.S. drug delivery market alone is estimated to reach $91 billion a year by 2009. Low-cost and flexible polymer synthesis techniques such as this technology will be poised to capture a major portion of this market.

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