Laser Treatment of Cutaneous Vascular Lesions

Life Sciences : Therapeutics

Available for licensing

Inventors

  • Gracie Vargas, Ph.D. , Biomedical Engineering
  • Thomas Milner, Ph.D. , Biomedical Engineering
  • Ashley Welch, Ph.D. , Biomedical Engineering
  • Jennifer Barton, Ph.D. , University of Arizona
  • Eric Chan, Ph.D. , University of Texas at Austin

Background/unmet need

Coagulate vessels often need multiple treatments before they can be destroyed. Current technologies are limited by the finite penetration depth of light and by the natural flow characteristics of blood vessels in tissue. As a result, clinical procedures are often unsuccessful at treating hypervascular lesions.

Invention Description

This invention is based on a parent patent and considered an extension. The laser doses required are dramatically reduced over other hypervascular lesion treatment methods by using hyperosmotic chemical agents applied prior to laser irradiation. These chemical agents include, but are not limited to, glycerol, dimethyl sulfoxide, sucrose, and glucose. After desired optical and morphological changes are induced, laser radiation is applied to the lesion-reducing scattering in the biological tissue and reduction and cessation of flow in arterioles and venules. The changes allow the laser to thus be more directly applied to the vessels and concurrently reduce the required energy to destroy a given vessel.

Benefits/Advantages

  • Reduces scattering in tissue
  • Reduces number of laser doses needed to destroy vessel
  • Changes from chemical agents alone are reversible
  • When coupled with laser radiation, use of agents results in permanent blood vessel coagulation

Features

    Delivers sufficient laser energy to a targeted blood vessel to destroy the vessel without damage to the epidermis and dermis Utilizes hyperosmotic chemical agents

Market potential/applications

Could have significant impact on the clinical treatment of hypervascular lesions or other subsurface tissue targets.

Development Stage

Proof of concept

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